ORGANIC NITRATES AS SYNTHETIC INTERMEDIATES: PREPARATIONS OF NITRATES AND SOME REPRESENTATIVE REACTIONS

Inorganic and Organic Nitrates as Sources of Nitric Oxide

Organic nitrates: past, present and future.

Nitric oxide (NO) is one of the most important vasodilator molecules produced by the endothelium. It has already been established that NO/cGMP signaling pathway deficiencies are involved in the pathophysiological mechanisms of many cardiovascular diseases. In this context, the development of NO-releasing drugs for therapeutic use appears to be an effective alternative to replace the deficient e...

NEAT HFpEF: Organic nitrates fail to deliver

Received: 8 November 2015 Accepted: 29 January 2016 c © 2016 The Author(s), licensee Magdi Yacoub Institute. This is an open access article distributed under the terms of the Creative Commons Attribution license CC BY-4.0, which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. Cite this article as: Wagdy K, Hassan M. NEAT HFpEF...

Some Effects of Nitrates in Bacteriological Media.

In the routine examination of faeces by means of the " screening " plate previously described (Knox, 1949) it was found that on certain batches of the medium known gas-producing organisms failed to produce gas from the mannitol. Since this was the first time that the medium had failed in over a year's routine use it was felt that an explanation would be of some interest. The explanation proved ...

Do we still need organic nitrates?

rganic nitrates are still quite frequently used for the reatment of acute and chronic angina, and acute and hronic congestive heart failure. When given acutely, their ffectiveness is undisputable; however, their long-term effiacy is substantially limited due to the development of olerance (1) and the induction of endothelial dysfunction (2), parameter that has prognostic significance in patient...